Two Secret Service agents, the intuitive Pete Lattimer and the by-the-book Myka Bering, are assigned by the enigmatic Mrs. Frederic to the mysterious Warehouse 13, in the South Dakota badlands.

Aubrey Fleming is a regular high school student with friends and family. One night, she unexpectedly disappears. Two weeks later she is found unconscious in the middle of the woods. When spoken to, her loved ones realize she has forgotten her identity and the personality living in her body is Dakota Moss, a character that Aubrey created in one of her stories for an English assignment. Dakota denies ever being Aubrey knowing that they look identical. Now, Dakota must try to unravel the mystery of how her and Aubrey co-exist and find out who abducted Aubrey that night.