After the events of Resident Evil: Extinction, the Alice clones (Jovovich) attempt to kill Albert Wesker (Roberts) at his base in Japan. All the clones are killed in an explosion as Wesker escapes in an aircraft. The original Alice ambushes him, but Wesker injects her with a serum that neutralizes the T-virus in her system, eliminating her superhuman powers and making her human again. Before he can kill her, the aircraft crashes and Alice emerges alone from the wreckage.