Years after the Raccoon City disaster, Alice is on her own; aware that she has become a liability and could endanger those around her, she is struggling to survive and bring down the Umbrella Corporation led by the sinister Albert Wesker and head researcher Dr. Isaacs. Meanwhile, traveling through the Nevada Desert and the ruins of Las Vegas, Carlos Olivera, L.J., and new survivors K-Mart, Claire Redfield, and Nurse Betty must fight to survive extinction against hordes of zombies, killer crows and the most terrifying creatures created as a result of the deadly T-Virus that has killed millions.

Traveling raccoon con artist, RJ, arrives in a woods outside a human city in the Midwest, excited about the wonders that living near humans can bring hungry animals. What he finds, however, is an Amish-like community that is deathly afraid of humans, after their leader, Vern the tortoise (Shandling), has an encounter with human boys that terrifies him.

Harold Lee and Kumar Patel are two stoners who end up getting the munchies. What they crave the most after seeing a TV advertisement, is a trip to White Castle. So from here, follows a journey for the burgers they require. On their way they will encounter many obstacles including a raccoon, a racist officer, and a horny Neil Patrick Harris.