Just before he's to marry Fiona, Roderick Blank receives an anonymous e-mail with 101 names on it; Fiona's is the 29th, the first 28 are women Rod has slept with, and the 30th turns out to be the stripper at his bachelor party. The notion that he will have sex with 70 more people sends Rod into crisis mode, especially after three odd men in an aseptic office confirm that a celestial machine has made an error. They suggest destroying the list, but Rod finds that easier said than done. Working his way through it consumes him, plus he realizes that death may await him after 101. Meanwhile, a femme fatale nicknamed Death Nell is putting men into a coma. Are they fated to meet?

Piers Gibbon and his volunteer patients attempt to unravel the mysteries of traditional Indian healing. Piers warns why you must never fall ill in India, when a man troubled by eczema braves bloodletting - an ancient treatment in which incisions are made into the skin with a razor blade to rid the body of bad blood. Practitioners of the therapy suggest that the darker the blood, the more the patient must bleed. They also test the benefits of cow urine. Piers Gibbon travels to India with Mark, who suffers from tinnitus and eczema, and Charles, who battles chronic migraines, to explore the healing properties of traditional local medicine. Guided by yoga master "Yogi Gi," the men start by using a rubber pipe to introduce a dollop of clarified butter into the nose. They also go under the knife for some vein slashing, get buried up to their necks in sand and finally sit down to reap the benefits of a tall glass of cow pee.